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Expression of beta-1,4-galactosyltransferase II and V in rat injured sciatic nerves.

Authors: Shen, A  Wang, H  Zhang, Y  Yan, J  Zhu, D  Gu, J 
Citation: Shen A, etal., Neurosci Lett 2002 Jul 12;327(1):45-8.
Pubmed: (View Article at PubMed) PMID:12098497

Beta-1,4-Galactosyltransferases II and V (beta-1,4-GalT II and V) are involved in the biosynthesis of N-linked oligosaccharides as beta-1,4-GalT I which plays important roles in promoting neuron outgrowth. In the present paper, it was illustrated that beta-1,4-GalT II and V were localized mainly in Schwann cells of lesion sciatic nerves by in situ hybridization. Northern blot showed that the expression of beta-1,4-GalT II increased gradually at both stumps of injured nerves, while that of beta-1,4-GalT V decreased at proximal stumps but increased and reached its peak on the third day post-operation at distal stumps, before it declined. The different expression of beta-1,4-GalT II and V in Schwann cells suggested that they would affect the different galactosylation of glycoproteins in injured nerves regeneration.


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CRRD Object Information
CRRD ID: 1302270
Created: 2004-09-07
Species: All species
Last Modified: 2006-04-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.