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Identification of a truncated IL-18R beta mRNA: a putative regulator of IL-18 expressed in rat brain.

Authors: Andre, R  Wheeler, RD  Collins, PD  Luheshi, GN  Pickering-Brown, S  Kimber, I  Rothwell, NJ  Pinteaux, E 
Citation: Andre R, etal., J Neuroimmunol 2003 Dec;145(1-2):40-5.
Pubmed: (View Article at PubMed) PMID:14644029

Interleukin (IL)-18, a member of the IL-1 family, is a key mediator of peripheral inflammation and host defense responses, and has been implicated in inflammatory and neurodegenerative diseases in the brain. IL-18 acts via a receptor complex that closely resembles that of IL-1, consisting of a ligand binding protein, IL-18Ralpha, and an accessory protein, IL-18Rbeta. Here, we describe the presence of a splice variant of IL-18Rbeta that is predicted to encode a truncated soluble protein, consisting of only the first immunoglobulin-like domain of IL-18Rbeta (EMBL/Genbank accession number AJ550893). Both forms of IL-18Rbeta were expressed in rat cortex, striatum, hypothalamus, hippocampus, and also liver, and were detected in pure cultures of microglia, astrocytes and neurons. This novel splice variant is up-regulated rapidly in microglial cells by bacterial lipopolyssacharide (LPS). We propose that this putative truncated form of IL-18Rbeta is analogous to the soluble form of IL-1R accessory protein, and could act as an important regulator of IL-18 actions.


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CRRD Object Information
CRRD ID: 1302389
Created: 2004-10-05
Species: All species
Last Modified: 2006-04-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.