Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

Genotypic association of exonic LGI4 polymorphisms and childhood absence epilepsy.

Authors: Gu, W  Sander, T  Becker, T  Steinlein, OK 
Citation: Gu W, etal., Neurogenetics 2004 Feb;5(1):41-4. Epub 2003 Sep 19.
Pubmed: (View Article at PubMed) PMID:14505228
DOI: Full-text: DOI:10.1007/s10048-003-0158-8

The LGI4 gene is located in a region linked to benign familial infantile convulsions (BFIC) and idiopathic generalized epilepsy. Screening of the LGI4 coding region in BFIC and childhood absence epilepsy (CAE) revealed several frequent exonic polymorphisms. A genotypic association was found for the c.1914GC --> AT polymorphism in 42 CAE patients compared with 110 population controls (chi2 = 6.66, df = 1, P = 0.01), providing evidence for a so far undetected susceptibility allele for CAE in the LGI4 region.


Disease Annotations
Objects Annotated

Additional Information

CRRD Object Information
CRRD ID: 1302591
Created: 2004-10-14
Species: All species
Last Modified: 2006-04-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.