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The calcineurin activity and MCIP1.4 mRNA levels are increased by innervation in regenerating soleus muscle.

Authors: Fenyvesi, R  Racz, G  Wuytack, F  Zador, E 
Citation: Fenyvesi R, etal., Biochem Biophys Res Commun 2004 Jul 23;320(2):599-605.
Pubmed: (View Article at PubMed) PMID:15219871
DOI: Full-text: DOI:10.1016/j.bbrc.2004.06.005

The level of active subunit of calcineurin and the calcineurin (Cn) enzyme activity are increased in innervated but not in denervated slow type regenerating skeletal soleus muscle. These nerve-dependent increases were not accompanied by similar increases in the mRNA levels. The changes in the mRNA level of the modulatory calcineurin interacting protein, MCIP1.4, reflected the calcineurin activity and did not increase in denervated regenerating muscles compared to the innervated regenerating controls. The increases in Cn activity and in MCIP1.4 mRNA levels occurred before the switch from fast to slow-type myosin heavy chain isoforms, a phenomenon similarly known to be dependent on innervation. This highlights the role of mediators, acting between the nerve and calcineurin, in the formation of slow fiber identity.


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CRRD Object Information
CRRD ID: 1304341
Created: 2004-12-22
Species: All species
Last Modified: 2004-12-22
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.