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Stage-specific enhanced expression of mitochondrial fusion and fission factors during spermatogenesis in rat testis.

Authors: Honda, Shinji  Hirose, Shigehisa 
Citation: Honda S and Hirose S, Biochem Biophys Res Commun. 2003 Nov 14;311(2):424-32.
Pubmed: (View Article at PubMed) PMID:14592431

The mitochondrial fusion factors mitofusins 1 and 2 (Mfn1 and Mfn2) and the fission factor dynamin-related protein 1 (Drp1) were found to be highly expressed in the pubertal and adult rat testis by Northern blot analysis. Immunohistochemistry using specific antisera to Mfn2 and Drp1 revealed a pronounced expression of the fusion and fission factors in the round and elongating spermatids in the seminiferous tubules, suggesting that at precise steps of spermiogenesis (i.e., steps 8-12), spermatid mitochondria are rapidly homogenized by frequent fusion and division. Although physiological relevance of this phenomenon remains to be clarified, a role is proposed for it as an effective means of achieving complete and homogeneous ubiquitination of mitochondria, which has recently been demonstrated to be a mechanism for the elimination of paternal mitochondria during fertilization, based on the fact that the timing of expression of Mfn2 and Drp1 coincides well with that reported for a spermatid-specific ubiquitin-conjugating enzyme.


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CRRD Object Information
CRRD ID: 13204840
Created: 2017-07-21
Species: All species
Last Modified: 2017-07-21
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.