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Salvia miltiorrhiza depresses plasminogen activator inhibitor-1 production through inhibition of angiotensin II.

Authors: Yuan, Jun  Wang, Xiaoqin  Chen, Taohou  Chen, Gang  Lu, Yanfang 
Citation: Yuan J, etal., Am J Chin Med. 2008;36(5):1005-15.
Pubmed: (View Article at PubMed) PMID:19051364
DOI: Full-text: DOI:10.1142/S0192415X08006405

The purpose of this study was to investigate the effect of Salvia miltiorrhiza on the production of plasminogen activator inhibitor-1(PAI-1) induced by angiotensin II (Ang II) in renal mesangial cells. Rat mesangial cells were exposed to 100 nM Ang II. Meanwhile, different concentrations of Salvia miltiorrhiza injection were added to Mesangial Cells. PAI-1 mRNA was measured by semi-quantification reverse transcriptase polymerase chain reaction (RT-PCR) and PAI-1 protein by Western blotting. ELISA was used to detect the expression of transforming growth factor beta(1) (TGF-beta(1)) in serum free MEM medium. The level of cellular reactive oxygen species (ROS) was measured by confocal laser scanning microscopy. Salvia miltiorrhiza notably attenuated expression of PAI-1 induced by Ang II in a concentration-dependent manner. Meanwhile, it suppressed the production of TGF-beta(1) and cellular ROS in mesangial cells. These effects were due to Salvia miltiorrhiza's ability of inhibiting the activities of angiotensin II. Therefore, Salvia miltiorrhiza can be used to retard progression of glomerular sclerosis.

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CRRD Object Information
CRRD ID: 13208594
Created: 2017-08-14
Species: All species
Last Modified: 2017-08-14
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.