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MicroRNA-30b functions as a tumour suppressor in human colorectal cancer by targeting KRAS, PIK3CD and BCL2.

Authors: Liao, Wen-Ting  Ye, Ya-Ping  Zhang, Nian-Jie  Li, Ting-Ting  Wang, Shu-Yang  Cui, Yan-Mei  Qi, Lu  Wu, Ping  Jiao, Hong-Li  Xie, Yi-Jun  Zhang, Chi  Wang, Jun-Xian  Ding, Yan-Qing 
Citation: Liao WT, etal., J Pathol. 2014 Mar;232(4):415-27. doi: 10.1002/path.4309.
Pubmed: (View Article at PubMed) PMID:24293274
DOI: Full-text: DOI:10.1002/path.4309

Colorectal cancer (CRC) is the third most common cancer in the USA. MicroRNAs play important roles in the pathogenesis of CRC. In this study, we investigated the role of miR-30b in CRC and found that its expression was significantly lower in CRC tissues than that in normal tissues. We showed that a low expression level of miR-30b was closely related to poor differentiation, advanced TNM stage and poor prognosis of CRC. Further experiments showed that over-expression of miR-30b suppressed CRC cell proliferation in vitro and tumour growth in vivo. Specifically, miR-30b promoted G1 arrest and induced apoptosis. Moreover, KRAS, PIK3CD and BCL2 were identified as direct and functional targets of miR-30b. MiR-30b directly targeted the 3'-untranslated regions of their mRNAs and repressed their expression. This study revealed functional and mechanistic links between miRNA-30b and oncogene KRAS, PIK3CD and BCL2 in the pathogenesis of CRC. MiR-30b not only plays important roles in the regulation of cell proliferation and tumour growth in CRC, but is also a potential prognostic marker or therapeutic target for CRC. Restoration of miR-30b expression may represent a promising therapeutic approach for targeting malignant CRC.


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CRRD Object Information
CRRD ID: 13432037
Created: 2017-09-13
Species: All species
Last Modified: 2017-09-13
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.