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Transforming growth factor beta1 suppresses nonmetastatic colon cancer at an early stage of tumorigenesis.

Authors: Engle, S J  Hoying, J B  Boivin, G P  Ormsby, I  Gartside, P S  Doetschman, T 
Citation: Engle SJ, etal., Cancer Res. 1999 Jul 15;59(14):3379-86.
Pubmed: (View Article at PubMed) PMID:10416598

The transforming growth factor beta (TGF-beta) pathway is known to play an important role in both human and urine colon cancer. However, the staging, ligand specificity, and mechanism underlying the tumor suppressive activity of this pathway are unknown. We developed a mouse model for colon cancer that identifies an early role for TGF-beta1 in tumor suppression and implicates TGF-beta2 or TGF-beta3 in the prevention of metastasis. Analysis of the development of colon cancer in TGF-beta1 knockout mice pinpoints the defect to the hyperplasty/adenoma transition and reveals that the mechanism involves an inability to maintain epithelial tissue organization and not a loss of growth control, increased inflammatory activity, or increased genetic instability. These mice provide a unique opportunity to investigate the specific role of TGF-beta1 at this critical transition in the development of colon cancer.


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CRRD Object Information
CRRD ID: 13432084
Created: 2017-09-19
Species: All species
Last Modified: 2017-09-19
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.