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Autism spectrum disorder susceptibility gene TAOK2 affects basal dendrite formation in the neocortex.

Authors: de Anda, Froylan Calderon  Rosario, Ana Lucia  Durak, Omer  Tran, Tracy  Gräff, Johannes  Meletis, Konstantinos  Rei, Damien  Soda, Takahiro  Madabhushi, Ram  Ginty, David D  Kolodkin, Alex L  Tsai, Li-Huei 
Citation: de Anda FC, etal., Nat Neurosci. 2012 Jun 10;15(7):1022-31. doi: 10.1038/nn.3141.
Pubmed: (View Article at PubMed) PMID:22683681
DOI: Full-text: DOI:10.1038/nn.3141

How neurons develop their morphology is an important question in neurobiology. Here we describe a new pathway that specifically affects the formation of basal dendrites and axonal projections in cortical pyramidal neurons. We report that thousand-and-one-amino acid 2 kinase (TAOK2), also known as TAO2, is essential for dendrite morphogenesis. TAOK2 downregulation impairs basal dendrite formation in vivo without affecting apical dendrites. Moreover, TAOK2 interacts with Neuropilin 1 (Nrp1), a receptor protein that binds the secreted guidance cue Semaphorin 3A (Sema3A). TAOK2 overexpression restores dendrite formation in cultured cortical neurons from Nrp1(Sema-) mice, which express Nrp1 receptors incapable of binding Sema3A. TAOK2 overexpression also ameliorates the basal dendrite impairment resulting from Nrp1 downregulation in vivo. Finally, Sema3A and TAOK2 modulate the formation of basal dendrites through the activation of the c-Jun N-terminal kinase (JNK). These results delineate a pathway whereby Sema3A and Nrp1 transduce signals through TAOK2 and JNK to regulate basal dendrite development in cortical neurons.

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CRRD Object Information
CRRD ID: 13461760
Created: 2017-11-25
Species: All species
Last Modified: 2017-11-25
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.