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Genome-wide association study identifies HLA-DP as a susceptibility gene for pediatric asthma in Asian populations.

Authors: Noguchi, Emiko  Sakamoto, Hiromi  Hirota, Tomomitsu  Ochiai, Kaori  Imoto, Yoshimasa  Sakashita, Masafumi  Kurosaka, Fumitake  Akasawa, Akira  Yoshihara, Shigemi  Kanno, Noriko  Yamada, Yumi  Shimojo, Naoki  Kohno, Yoichi  Suzuki, Yoichi  Kang, Mi-Jin  Kwon, Ji-Won  Hong, Soo-Jong  Inoue, Ken  Goto, Yu-Ichi  Yamashita, Fumio  Asada, Takashi  Hirose, Hiroshi  Saito, Ikuo  Fujieda, Shigeharu  Hizawa, Nobuyuki  Sakamoto, Toru  Masuko, Hironori  Nakamura, Yusuke  Nomura, Ichiro  Tamari, Mayumi  Arinami, Tadao  Yoshida, Teruhiko  Saito, Hirohisa  Matsumoto, Kenji 
Citation: Noguchi E, etal., PLoS Genet. 2011 Jul;7(7):e1002170. doi: 10.1371/journal.pgen.1002170. Epub 2011 Jul 21.
Pubmed: (View Article at PubMed) PMID:21814517
DOI: Full-text: DOI:10.1371/journal.pgen.1002170

Asthma is a complex phenotype influenced by genetic and environmental factors. We conducted a genome-wide association study (GWAS) with 938 Japanese pediatric asthma patients and 2,376 controls. Single-nucleotide polymorphisms (SNPs) showing strong associations (P<1×10(-8)) in GWAS were further genotyped in an independent Japanese samples (818 cases and 1,032 controls) and in Korean samples (835 cases and 421 controls). SNP rs987870, located between HLA-DPA1 and HLA-DPB1, was consistently associated with pediatric asthma in 3 independent populations (P(combined) = 2.3×10(-10), odds ratio [OR] = 1.40). HLA-DP allele analysis showed that DPA1*0201 and DPB1*0901, which were in strong linkage disequilibrium, were strongly associated with pediatric asthma (DPA1*0201: P = 5.5×10(-10), OR = 1.52, and DPB1*0901: P = 2.0×10(-7), OR = 1.49). Our findings show that genetic variants in the HLA-DP locus are associated with the risk of pediatric asthma in Asian populations.

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CRRD Object Information
CRRD ID: 13506911
Created: 2018-02-22
Species: All species
Last Modified: 2018-02-22
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.