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Genetic variants in the major histocompatibility complex class I and class II genes are associated with diisocyanate-induced Asthma.

Authors: Yucesoy, Berran  Johnson, Victor J  Lummus, Zana L  Kashon, Michael L  Rao, Marepalli  Bannerman-Thompson, Hansen  Frye, Bonnie  Wang, Wei  Gautrin, Denyse  Cartier, AndrĂ©  Boulet, Louis-Philippe  Sastre, Joaquin  Quirce, Santiago  Tarlo, Susan M  Germolec, Dori R  Luster, Michael I  Bernstein, David I 
Citation: Yucesoy B, etal., J Occup Environ Med. 2014 Apr;56(4):382-7. doi: 10.1097/JOM.0000000000000138.
Pubmed: (View Article at PubMed) PMID:24709764
DOI: Full-text: DOI:10.1097/JOM.0000000000000138


OBJECTIVE: To investigate the association between single nucleotide polymorphisms (SNPs) located across the major histocompatibility complex and susceptibility to diisocyanate-induced asthma (DA).
METHODS: The study population consisted of 140 diisocyanate-exposed workers. Genotyping was performed using the Illumina GoldenGate major histocompatibility complex panels.
RESULTS: The HLA-E rs1573294 and HLA-DPB1 rs928976 SNPs were associated with an increased risk of DA under dominant (odds ratio [OR], 6.27; 95% confidence interval [CI], 2.37 to 16.6; OR, 2.79, 95% CI, 0.99 to 7.81, respectively) and recessive genetic models (OR, 6.27, 95% CI, 1.63 to 24.13; OR, 10.10, 95% CI, 3.16 to 32.33, respectively). The HLA-B rs1811197, HLA-DOA rs3128935, and HLA-DQA2 rs7773955 SNPs conferred an increased risk of DA in a dominant model (OR, 7.64, 95% CI, 2.25 to 26.00; OR, 19.69, 95% CI, 2.89 to 135.25; OR, 8.43, 95% CI, 3.03 to 23.48, respectively).
CONCLUSION: These results suggest that genetic variations within HLA genes play a role in DA risk.

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CRRD Object Information
CRRD ID: 13506912
Created: 2018-02-22
Species: All species
Last Modified: 2018-02-22
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.