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[Expression of eosinophil major basic protein mRNA in bronchial asthma].

Authors: Li, Shuang-hong  Luo, Ya-ling  Lai, Wen-yan 
Citation: Li SH, etal., Nan Fang Yi Ke Da Xue Xue Bao. 2006 Sep;26(9):1330-3.
Pubmed: (View Article at PubMed) PMID:16982448

OBJECTIVE: To investigate the expression of eosinophil major basic protein (MBP) mRNA in bronchial asthma and explore its significance.
METHODS: Peripheral blood eosinophil MBP mRNA levels were measured in 40 patients with asthma and 20 normal controls by semi-quantitative RT-PCR. The association of MBP mRNA levels with eosinophil count and pulmonary function was also analyzed.
RESULTS: Compared with the normal control group, MBP mRNA level were significantly increased in asthma patients (0.37-/+0.11 vs 0.17-/+0.04, P<0.001), so was the eosinophil count (0.86-/+0.52 vs 0.21-/+0.10, P<0.001). MBP mRNA levels in patients with moderate persistent asthma (0.42-/+0.05) and those with severe persistent asthma (0.47-/+0.05) were significantly higher than those in patients with mild persistent asthma (0.25-/+0.06, P<0.001), and the difference in MBP mRNA levels between moderate persistent asthma patients and severe ones was also significant (P<0.05). Among the asthma patients, MBP mRNA levels showed an inverse correlation with pulmonary function (r=-0.7490, P<0.001).
CONCLUSION: Increased MBP mRNA expression level may correlate with the severity of asthma. MBP may play an important role in the development of asthma.


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CRRD Object Information
CRRD ID: 13506941
Created: 2018-02-26
Species: All species
Last Modified: 2018-02-26
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.