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Eosinophil major basic protein-1 does not contribute to allergen-induced airway pathologies in mouse models of asthma.

Authors: Denzler, K L  Farmer, S C  Crosby, J R  Borchers, M  Cieslewicz, G  Larson, K A  Cormier-Regard, S  Lee, N A  Lee, J J 
Citation: Denzler KL, etal., J Immunol. 2000 Nov 15;165(10):5509-17.
Pubmed: (View Article at PubMed) PMID:11067904

The relationship between eosinophils and the development of Ag-induced pulmonary pathologies, including airway hyper-responsiveness, was investigated using mice deficient for the secondary granule component, major basic protein-1 (mMBP-1). The loss of mMBP-1 had no effect on OVA-induced airway histopathologies or inflammatory cell recruitment. Lung function measurements of knockout mice demonstrated a generalized hyporeactivity to methacholine-induced airflow changes (relative to wild type); however, this baseline phenotype was observable only with methacholine; no relative airflow changes were observed in response to another nonspecific stimulus (serotonin). Moreover, OVA sensitization/aerosol challenge of wild-type and mMBP-1(-/-) mice resulted in identical dose-response changes to either methacholine or serotonin. Thus, the airway hyper-responsiveness in murine models of asthma occurs in the absence of mMBP-1.


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CRRD Object Information
CRRD ID: 13506942
Created: 2018-02-26
Species: All species
Last Modified: 2018-02-26
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.