MHC2TA is associated with differential MHC molecule expression and susceptibility to rheumatoid arthritis, multiple sclerosis and myocardial infarction.

Authors: Swanberg, M  Lidman, O  Padyukov, L  Eriksson, P  Akesson, E  Jagodic, M  Lobell, A  Khademi, M  Borjesson, O  Lindgren, CM  Lundman, P  Brookes, AJ  Kere, J  Luthman, H  Alfredsson, L  Hillert, J  Klareskog, L  Hamsten, A  Piehl, F  Olsson, T 
Citation: Swanberg M, etal., Nat Genet 2005 May;37(5):486-94. Epub 2005 Apr 10.
Pubmed: (View Article at PubMed) PMID:15821736
DOI: Full-text: DOI:10.1038/ng1544

Antigen presentation to T cells by MHC molecules is essential for adaptive immune responses. To determine the exact position of a gene affecting expression of MHC molecules, we finely mapped a previously defined rat quantitative trait locus regulating MHC class II on microglia in an advanced intercross line. We identified a small interval including the gene MHC class II transactivator (Mhc2ta) and, using a map over six inbred strains combined with gene sequencing and expression analysis, two conserved Mhc2ta haplotypes segregating with MHC class II levels. In humans, a -168A --> G polymorphism in the type III promoter of the MHC class II transactivator (MHC2TA) was associated with increased susceptibility to rheumatoid arthritis, multiple sclerosis and myocardial infarction, as well as lower expression of MHC2TA after stimulation of leukocytes with interferon-gamma. We conclude that polymorphisms in Mhc2ta and MHC2TA result in differential MHC molecule expression and are associated with susceptibility to common complex diseases with inflammatory components.

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CRRD ID: 1358146
Created: 2005-05-12
Species: All species
Last Modified: 2005-05-12
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.