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Reelin promotes peripheral synapse elimination and maturation.

Authors: Quattrocchi, CC  Huang, C  Niu, S  Sheldon, M  Benhayon, D  Cartwright J, JR  Mosier, DR  Keller, F  D'Arcangelo, G 
Citation: Quattrocchi CC, etal., Science 2003 Aug 1;301(5633):649-53.
Pubmed: (View Article at PubMed) PMID:12893944
DOI: Full-text: DOI:10.1126/science.1082690

Reelin is an extracellular protein that is crucial for layer formation in the embryonic brain. Here, we demonstrate that Reelin functions postnatally to regulate the development of the neuromuscular junction. Reelin is required for motor end-plate maturation and proper nerve-muscle connectivity, and it directly promotes synapse elimination. Unlike layer formation, neuromuscular junction development requires a function of Reelin that is not mediated by Disabled1 or very-low-density lipoprotein receptors and apolipoprotein E receptor 2 receptors but by a distinct mechanism involving its protease activity.


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CRRD Object Information
CRRD ID: 1358346
Created: 2005-06-09
Species: All species
Last Modified: 2005-06-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.