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An intracellular protein that binds amyloid-beta peptide and mediates neurotoxicity in Alzheimer's disease.

Authors: Yan, SD  Fu, J  Soto, C  Chen, X  Zhu, H  Al-Mohanna, F  Collison, K  Zhu, A  Stern, E  Saido, T  Tohyama, M  Ogawa, S  Roher, A  Stern, D 
Citation: Yan SD, etal., Nature 1997 Oct 16;389(6652):689-95.
Pubmed: (View Article at PubMed) PMID:9338779
DOI: Full-text: DOI:10.1038/39522

Amyloid-beta is a neurotoxic peptide which is implicated in the pathogenesis of Alzheimer's disease. It binds an intracellular polypeptide known as ERAB, thought to be a hydroxysteroid dehydrogenase enzyme, which is expressed in normal tissues, but is overexpressed in neurons affected in Alzheimer's disease. ERAB immunoprecipitates with amyloid-beta, and when cell cultures are exposed to amyloid-beta, ERAB inside the cell is rapidly redistributed to the plasma membrane. The toxic effect of amyloid-beta on these cells is prevented by blocking ERAB and is enhanced by overexpression of ERAB. By interacting with intracellular amyloid-beta, ERAB may therefore contribute to the neuronal dysfunction associated with Alzheimer's disease.


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CRRD Object Information
CRRD ID: 1358426
Created: 2005-06-11
Species: All species
Last Modified: 2005-06-11
Status: ACTIVE


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