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Role of cholecystokinin-A and cholecystokinin-B receptors in anxiety.

Authors: Hernandez-Gomez, AM  Aguilar-Roblero, R  Perez de la Mora, M 
Citation: Hernandez-Gomez AM, etal., Amino Acids 2002;23(1-3):283-90.
Pubmed: (View Article at PubMed) PMID:12373548
DOI: Full-text: DOI:10.1007/s00726-001-0139-x

Evidence from several laboratories indicates that the anxiogenic effects of cholecystokinin (CCK) are mediated by CCKB receptors. However, it has been reported that CCKA receptors have been found in brain and CCKA antagonists have anxiolytic properties. The aim of this work was to study whether CCKA receptors are also involved in the modulation of anxiety. Anxiogenic effects were observed in the elevated plus maze in rats when pure CCKB receptor agonists (CCK-4 and CCK-8 non-sulfated) or CCK-8S, a CCKB/CCKA agonist, were injected into the lateral ventricle. In contrast, CCK-33, a CCKA agonist or CCK-(1-21) and CCK-(26-29) were ineffective. Furthermore, the anxiogenic effects of CCK-8S were prevented by blocking CCKB but not CCKA receptors. Finally, CCK-33 injected into the postero-medial nucleus accumbens failed to affect the anxiety level of the rats. These results indicate that CCKA receptors are not involved in anxiety, as measured by the paradigms used in this work.

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CRRD Object Information
CRRD ID: 1358453
Created: 2005-06-13
Species: All species
Last Modified: 2005-06-13
Status: ACTIVE



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