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The reelin signaling pathway: some recent developments.

Authors: Jossin, Y  Bar, I  Ignatova, N  Tissir, F  De Rouvroit, CL  Goffinet, AM 
Citation: Jossin Y, etal., Cereb Cortex 2003 Jun;13(6):627-33.
Pubmed: (View Article at PubMed) PMID:12764038

The Reelin signaling pathway plays a key role in the architectonic development of the central nervous system. Extracellular Reelin binds to receptors of the lipoprotein receptor family and induces tyrosine phosphorylation of the adaptor Dab1. In this paper, we discuss three recent developments. First, we show that the central part of Reelin is involved in receptor binding and signal activation as reflected in Dab1 phosphorylation. Second, we examine the genomic organization, alternative splicing and promoter use of the Dab1 gene, which hint at a particularly complex regulation. Third, we present preliminary studies by in situ hybridization that demonstrate regulated expression of Reelin receptors and Dab1 by radial precursors in the ventricular zone.


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CRRD Object Information
CRRD ID: 1358468
Created: 2005-06-13
Species: All species
Last Modified: 2005-06-13
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.