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A DLST genotype associated with reduced risk for Alzheimer's disease.

Authors: Sheu, KF  Brown, AM  Kristal, BS  Kalaria, RN  Lilius, L  Lannfelt, L  Blass, JP 
Citation: Sheu KF, etal., Neurology 1999 Apr 22;52(7):1505-7.
Pubmed: (View Article at PubMed) PMID:10227647

Recent studies suggest that variants of the DLST gene alter the risk of AD. DLST encodes the core subunit of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which is deficient in AD. The authors report that in 247 US white subjects, homozygosity for DLST A19,117, T19,183 was associated with a reduced risk of AD (odds ratio [OR] = 0.35, p = 0.018). The reduced risk was marked in subjects who did not carry the apolipoprotein (APOE)-4 allele (OR = 0.16, p = 0.014). Further study of DLST in AD appears warranted.


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CRRD Object Information
CRRD ID: 1358587
Created: 2005-06-16
Species: All species
Last Modified: 2005-06-16
Status: ACTIVE


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