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Positive association between the GABRA5 gene and unipolar recurrent major depression.

Authors: Oruc, L  Verheyen, GR  Furac, I  Ivezic, S  Jakovljevic, M  Raeymaekers, P  Van Broeckhoven, C 
Citation: Oruc L, etal., Neuropsychobiology 1997;36(2):62-4.
Pubmed: (View Article at PubMed) PMID:9267853

The gamma-aminobutyric acid (GABA) neurotransmitter system has been implicated in the pathogenesis of mood disorders. To test this hypothesis we carried out an association study between a dinucleotide repeat polymorphism in the GABAA receptor alpha 5 subunit gene and bipolar and unipolar mood disorders. Our results suggest a possible involvement of this gene in unipolar but not in bipolar disorder.


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CRRD Object Information
CRRD ID: 1358629
Created: 2005-06-20
Species: All species
Last Modified: 2005-06-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.