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Association of interleukin-1 gene polymorphisms with Alzheimer's disease.

Authors: Nicoll, JA  Mrak, RE  Graham, DI  Stewart, J  Wilcock, G  MacGowan, S  Esiri, MM  Murray, LS  Dewar, D  Love, S  Moss, T  Griffin, WS 
Citation: Nicoll JA, etal., Ann Neurol 2000 Mar;47(3):365-8.
Pubmed: (View Article at PubMed) PMID:10716257

Interleukin-1 (IL-1) is markedly overexpressed in Alzheimer's disease. We found the IL-1A 2,2 genotype in 12.9% of 232 neuropathologically confirmed Alzheimer's disease patients and 6.6% of 167 controls from four centers in the United Kingdom and United States (odds ratio, 3.0; controlled for age and for ApoE [apolipoprotein E] genotype). Homozygosity for both allele 2 of IL-1A and allele 2 of IL-1B conferred even greater risk (odds ratio, 10.8). IL-1 genotypes may confer risk for Alzheimer's disease through IL-1 overexpression and IL-1-driven neurodegenerative cascades.

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CRRD Object Information
CRRD ID: 1358667
Created: 2005-06-23
Species: All species
Last Modified: 2005-06-23
Status: ACTIVE



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