The arrestin domain-containing 3 protein regulates body mass and energy expenditure.

Authors: Patwari, Parth  Emilsson, Valur  Schadt, Eric E  Chutkow, William A  Lee, Samuel  Marsili, Alessandro  Zhang, Yongzhao  Dobrin, Radu  Cohen, David E  Larsen, P Reed  Zavacki, Ann Marie  Fong, Loren G  Young, Stephen G  Lee, Richard T 
Citation: Patwari P, etal., Cell Metab. 2011 Nov 2;14(5):671-83. doi: 10.1016/j.cmet.2011.08.011. Epub 2011 Oct 6.
Pubmed: (View Article at PubMed) PMID:21982743
DOI: Full-text: DOI:10.1016/j.cmet.2011.08.011

A human genome-wide linkage scan for obesity identified a linkage peak on chromosome 5q13-15. Positional cloning revealed an association of a rare haplotype to high body-mass index (BMI) in males but not females. The risk locus contains a single gene, "arrestin domain-containing 3" (ARRDC3), an uncharacterized α-arrestin. Inactivating Arrdc3 in mice led to a striking resistance to obesity, with greater impact on male mice. Mice with decreased ARRDC3 levels were protected from obesity due to increased energy expenditure through increased activity levels and increased thermogenesis of both brown and white adipose tissues. ARRDC3 interacted directly with ß-adrenergic receptors, and loss of ARRDC3 increased the response to ß-adrenergic stimulation in isolated adipose tissue. These results demonstrate that ARRDC3 is a gender-sensitive regulator of obesity and energy expenditure and reveal a surprising diversity for arrestin family protein functions.


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CRRD Object Information
CRRD ID: 13673828
Created: 2018-06-23
Species: All species
Last Modified: 2018-06-23
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.