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Huntingtin-associated protein 1 regulates inhibitory synaptic transmission by modulating gamma-aminobutyric acid type A receptor membrane trafficking.

Authors: Kittler, Josef T  Thomas, Philip  Tretter, Verena  Bogdanov, Yuri D  Haucke, Volker  Smart, Trevor G  Moss, Stephen J 
Citation: Kittler JT, etal., Proc Natl Acad Sci U S A. 2004 Aug 24;101(34):12736-41. doi: 10.1073/pnas.0401860101. Epub 2004 Aug 13.
Pubmed: (View Article at PubMed) PMID:15310851
DOI: Full-text: DOI:10.1073/pnas.0401860101

Gamma-aminobutyric acid type A receptors (GABA(A)Rs) are the major sites of fast synaptic inhibition in the brain. An essential determinant for the efficacy of synaptic inhibition is the regulation of GABA(A)R cell surface stability. Here, we have examined the regulation of GABA(A)R endocytic sorting, a critical regulator of cell surface receptor number. In neurons, rapid constitutive endocytosis of GABA(A)Rs was evident. Internalized receptors were then either rapidly recycled back to the cell surface, or on a slower time scale, targeted for lysosomal degradation. This sorting decision was regulated by a direct interaction of GABA(A)Rs with Huntingtin-associated protein 1 (HAP1). HAP1 modulated synaptic GABA(A)R number by inhibiting receptor degradation and facilitating receptor recycling. Together these observations have identified a role for HAP1 in regulating GABA(A)R sorting, suggesting an important role for this protein in the construction and maintenance of inhibitory synapses.


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CRRD Object Information
CRRD ID: 13702182
Created: 2018-07-18
Species: All species
Last Modified: 2018-07-18
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.