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Ring finger protein 10 is a novel synaptonuclear messenger encoding activation of NMDA receptors in hippocampus.

Authors: Dinamarca, Margarita C  Guzzetti, Francesca  Karpova, Anna  Lim, Dmitry  Mitro, Nico  Musardo, Stefano  Mellone, Manuela  Marcello, Elena  Stanic, Jennifer  Samaddar, Tanmoy  Burguière, Adeline  Caldarelli, Antonio  Genazzani, Armando A  Perroy, Julie  Fagni, Laurent  Canonico, Pier Luigi  Kreutz, Michael R  Gardoni, Fabrizio  Di Luca, Monica 
Citation: Dinamarca MC, etal., Elife. 2016 Mar 15;5:e12430. doi: 10.7554/eLife.12430.
Pubmed: (View Article at PubMed) PMID:26977767
DOI: Full-text: DOI:10.7554/eLife.12430

Synapses and nuclei are connected by bidirectional communication mechanisms that enable information transfer encoded by macromolecules. Here, we identified RNF10 as a novel synaptonuclear protein messenger. RNF10 is activated by calcium signals at the postsynaptic compartment and elicits discrete changes at the transcriptional level. RNF10 is enriched at the excitatory synapse where it associates with the GluN2A subunit of NMDA receptors (NMDARs). Activation of synaptic GluN2A-containing NMDARs and induction of long term potentiation (LTP) lead to the translocation of RNF10 from dendritic segments and dendritic spines to the nucleus. In particular, we provide evidence for importin-dependent long-distance transport from synapto-dendritic compartments to the nucleus. Notably, RNF10 silencing prevents the maintenance of LTP as well as LTP-dependent structural modifications of dendritic spines.

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CRRD Object Information
CRRD ID: 13702335
Created: 2018-07-18
Species: All species
Last Modified: 2018-07-18
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.