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Localization of Rabphilin-3A on the synaptic vesicle.

Authors: Mizoguchi, A  Yano, Y  Hamaguchi, H  Yanagida, H  Ide, C  Zahraoui, A  Shirataki, H  Sasaki, T  Takai, Y 
Citation: Mizoguchi A, etal., Biochem Biophys Res Commun. 1994 Aug 15;202(3):1235-43. doi: 10.1006/bbrc.1994.2063.
Pubmed: (View Article at PubMed) PMID:8060298
DOI: Full-text: DOI:10.1006/bbrc.1994.2063

Rabphilin-3A is a putative target protein for Rab3A small GTP-binding protein which is implicated in neurotransmitter release. Rabphilin-3A is expressed mainly in brain, but its subcellular localization remains to be clarified. Immunohistochemical analysis has revealed that Rabphilin-3A is most abundant in the synaptic area of the rat cerebellum, retina, and neuromuscular junction. Ultrastructural analysis of the neuromuscular junction using the immunogold method indicates that Rabphilin-3A is localized on the synaptic vesicle. Subcellular fractionation analysis of rat brain has shown that Rabphilin-3A is most highly concentrated in the purified synaptic vesicle fraction. These results indicate that Rabphilin-3A is localized on the synaptic vesicle in the presynapse.


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CRRD Object Information
CRRD ID: 13702383
Created: 2018-07-18
Species: All species
Last Modified: 2018-07-18
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.