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Hippocampal long-term potentiation and neural cell adhesion molecules L1 and NCAM.

Authors: Lüthl, A  Laurent, J P  Figurov, A  Muller, D  Schachner, M 
Citation: Lüthl A, etal., Nature. 1994 Dec 22-29;372(6508):777-9. doi: 10.1038/372777a0.
Pubmed: (View Article at PubMed) PMID:7997264
DOI: Full-text: DOI:10.1038/372777a0

Synaptic membranes express cell adhesion molecules. Here we investigate the role of the neural cell adhesion molecules L1 and NCAM in hippocampal long-term potentiation (LTP), a sustained-use-dependent increase in synaptic efficacy that has been implicated in learning and memory. L1 and NCAM mediate cell interactions during neural development and are strongly expressed in the hippocampus. They cooperate to strengthen L1-dependent cell adhesion and are coupled to second messenger pathways. We show that LTP in CA1 neurons of rat hippocampal slices was reduced by application of various L1 and NCAM antibodies, recombinant L1 fragments, and upon dissociation of the L1/NCAM complex through oligomannosidic carbohydrates and NCAM peptides. Neither the activation of NMDA (N-methyl-D-aspartate) receptors nor the maintenance of LTP was affected. These results suggest that L1 and NCAM modulate the development or the stabilization of LTP.


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CRRD Object Information
CRRD ID: 13702438
Created: 2018-07-18
Species: All species
Last Modified: 2018-07-18
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.