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Essential role for Ras signaling in glioblastoma maintenance.

Authors: Holmen, Sheri L  Williams, Bart O 
Citation: Holmen SL and Williams BO, Cancer Res. 2005 Sep 15;65(18):8250-5. doi: 10.1158/0008-5472.CAN-05-1173.
Pubmed: (View Article at PubMed) PMID:16166301
DOI: Full-text: DOI:10.1158/0008-5472.CAN-05-1173

Malignant gliomas can be induced in mice through the combined expression of activated forms of both KRas and Akt in glial progenitor cells. To determine the reliance of these tumors on continued KRas signaling in vivo, we generated a viral vector that allows the expression of KRas to be controlled post-delivery. Tumor-free survival rates were compared between those animals with continued KRas expression and animals in which KRas expression was suppressed. KRas signaling was found to be required for the maintenance of these tumors in vivo; inhibition of KRas expression resulted in apoptotic tumor regression and increased survival. Subsequent reexpression of KRas reinitiated tumor growth, indicating that a percentage of the progenitor cells survived and retained tumorigenic properties.


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CRRD Object Information
CRRD ID: 13702861
Created: 2018-07-19
Species: All species
Last Modified: 2018-07-19
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.