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Proteomics studies of childhood pilocytic astrocytoma.

Authors: Anagnostopoulos, Athanasios K  Dimas, Konstantinos S  Papathanassiou, Chrissa  Braoudaki, Maria  Anastasiadou, Ema  Vougas, Konstantinos  Karamolegou, Kalliopi  Kontos, Harry  Prodromou, Neofytos  Tzortzatou-Stathopoulou, Fotini  Tsangaris, George Th 
Citation: Anagnostopoulos AK, etal., J Proteome Res. 2011 May 6;10(5):2555-65. doi: 10.1021/pr200024m. Epub 2011 Apr 14.
Pubmed: (View Article at PubMed) PMID:21466243
DOI: Full-text: DOI:10.1021/pr200024m

Childhood pilocytic astrocytoma is the most frequent brain tumor affecting children. Proteomics analysis is currently considered a powerful tool for global evaluation of protein expression and has been widely applied in the field of cancer research. In the present study, a series of proteomics, genomics, and bioinformatics approaches were employed to identify, classify and characterize the proteome content of low-grade brain tumors as it appears in early childhood. Through bioinformatics database construction, protein profiles generated from pathological tissue samples were compared against profiles of normal brain tissues. Additionally, experiments of comparative genomic hybridization arrays were employed to monitor for genetic aberrations and sustain the interpretation and evaluation of the proteomic data. The current study confirms the dominance of MAPK pathway for the childhood pilocytic astrocytoma occurrence and novel findings regarding the ERK-2 expression are reported.


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CRRD Object Information
CRRD ID: 13702864
Created: 2018-07-20
Species: All species
Last Modified: 2018-07-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.