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The protective effects of tadalafil on renal damage following ischemia reperfusion injury in rats.

Authors: Erol, Bulent  Turker, Tugrul  Tok, Adem  Bektas, Sibel  Mungan, Gorkem  Ozkanli, Seyma  Karakas, Bugra  Tokgoz, Husnu  Akduman, Bulent  Mungan, Aydin 
Citation: Erol B, etal., Kaohsiung J Med Sci. 2015 Sep;31(9):454-62. doi: 10.1016/j.kjms.2015.06.005. Epub 2015 Jul 22.
Pubmed: (View Article at PubMed) PMID:26362957
DOI: Full-text: DOI:10.1016/j.kjms.2015.06.005

Ischemia-reperfusion injury can cause renal damage, and phosphodiesterase inhibitors are reported to regulate antioxidant activity. We investigated the prevention of renal damage using tadalafil after renal ischemia reperfusion (I/R) injury in rats. A total of 21 adult male Wistar albino rats were randomly divided into three groups of seven, including Group 1-control, Group 2-I/R, and Group 3-tadalafil + I/R group (I/R-T group) received tadalafil intraperitoneally at 30 minutes before ischemia. Inducible nitric oxide synthase, endothelial nitric oxide synthase, malondialdehyde, and total antioxidant capacity levels were evaluated, and histopathological changes and apoptosis in the groups were examined. Tadalafil decreased malondialdehyde levels in the I/R group and increased the total antioxidant capacity level. Histopathological and immunohistochemical findings revealed that tadalafil decreased renal injury scores and the ratios of injured cells, as measured through apoptotic protease activating factor 1, inducible nitric oxide synthase, and endothelial nitric oxide synthase levels. We suggest that tadalafil has protective effects against I/R-related renal tissue injury.


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CRRD Object Information
CRRD ID: 13703110
Created: 2018-08-01
Species: All species
Last Modified: 2018-08-01
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.