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Salidroside protects PC12 cells from Aß1-40-induced cytotoxicity by regulating the nicotinamide phosphoribosyltransferase signaling pathway.

Authors: Huang, Xujiao  Xing, Sanli  Chen, Chuan  Yu, Zhihua  Chen, Jiulin 
Citation: Huang X, etal., Mol Med Rep. 2017 Sep;16(3):2700-2706. doi: 10.3892/mmr.2017.6931. Epub 2017 Jul 5.
Pubmed: (View Article at PubMed) PMID:28714019
DOI: Full-text: DOI:10.3892/mmr.2017.6931

Alzheimer's disease (AD) is the most common type of senile dementia, which often develops in elderly or presenile individuals. As one of the pathological features of AD, amyloid ß-protein (Aß) causes energy dysmetabolism, thereby inducing cellular damage and apoptosis. Salidroside is the main active component of the traditional Chinese medicine Rhodiola. Previous studies have demonstrated that salidroside exerts a regulatory role in energy metabolism. However, the role and the mechanism of action of salidroside in AD remain unclear. Therefore, the present study used Aß1-40 to induce damage in PC12 cells, thereby establishing a cell model of AD. In addition, salidroside treatment was performed to investigate the protective effect of salidroside and the underlying mechanisms. Aß1-40-induced neuronal toxicity reduced cell viability and caused cellular damage. As a result, the expression level of nicotinamide phosphoribosyltransferase (NAMPT) decreased, the synthesis of nicotinamide adenine dinucleotide (NAD+; an energy metabolism-associated coenzyme) became insufficient, and the NAD+/nicotinamide adenine dinucleotide hydride ratio was reduced. Administration of salidroside alleviated Aß-induced cell damage and increased the expression level of the key protein NAMPT and the synthesis of NAD+. The results of the present study demonstrate that salidroside exerts a protective effect on Aß1-40-damaged PC12 cells. The underlying mechanism may be associated with the regulation of energy metabolism that relies predominantly on the NAMPT signaling pathway.


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CRRD Object Information
CRRD ID: 13781878
Created: 2018-08-09
Species: All species
Last Modified: 2018-08-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.