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The DEAH-box helicase DHX36 mediates dendritic localization of the neuronal precursor-microRNA-134.

Authors: Bicker, Silvia  Khudayberdiev, Sharof  WeiƟ, Kerstin  Zocher, Kathleen  Baumeister, Stefan  Schratt, Gerhard 
Citation: Bicker S, etal., Genes Dev. 2013 May 1;27(9):991-6. doi: 10.1101/gad.211243.112.
Pubmed: (View Article at PubMed) PMID:23651854
DOI: Full-text: DOI:10.1101/gad.211243.112

Specific microRNAs (miRNAs), including miR-134, localize to neuronal dendrites, where they control synaptic protein synthesis and plasticity. However, the mechanism of miRNA transport is unknown. We found that the neuronal precursor-miRNA-134 (pre-miR-134) accumulates in dendrites of hippocampal neurons and at synapses in vivo. Dendritic localization of pre-miR-134 is mediated by the DEAH-box helicase DHX36, which directly associates with the pre-miR-134 terminal loop. DHX36 function is required for miR-134-dependent inhibition of target gene expression and the control of dendritic spine size. Dendritically localized pre-miR-134 could provide a local source of miR-134 that can be mobilized in an activity-dependent manner during plasticity.


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CRRD Object Information
CRRD ID: 13792545
Created: 2018-09-12
Species: All species
Last Modified: 2018-09-12
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.