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Fas Ligand Gene (Faslg) Plays an Important Role in Nerve Degeneration and Regeneration After Rat Sciatic Nerve Injury.

Authors: Li, Yuting  Sun, Yuhua  Cai, Min  Zhang, Huanhuan  Gao, Nannan  Huang, Huiwei  Cui, Shusen  Yao, Dengbing 
Citation: Li Y, etal., Front Mol Neurosci. 2018 Jun 19;11:210. doi: 10.3389/fnmol.2018.00210. eCollection 2018.
Pubmed: (View Article at PubMed) PMID:29970988
DOI: Full-text: DOI:10.3389/fnmol.2018.00210

Wallerian degeneration (WD) is associated with changes in the expression levels of a large number of genes. However, the effects of these up- or down-regulated genes are poorly understood. We have reported some key factors that are differentially regulated during WD in our previous research. Here, we explored the roles of Fas ligand gene (Faslg) in WD after rat sciatic nerve injury. The data showed that Faslg was up-regulated in injured nerves. Expression changed of Faslg in Schwann cells (SCs) resulted in alterations in the release of related factors. Silencing or overexpression of Faslg affected SC proliferation, migration, and apoptosis through ß-catenin, nuclear factor-κB (NF-κB), and caspase-3 pathways in vivo and in vitro. Our data suggest that Faslg is a key regulatory gene that affects nerve repair and regeneration in peripheral nerve injury. This study sheds new light on the effects of Faslg on peripheral nerve degeneration and/or regeneration.

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CRRD Object Information
CRRD ID: 13792563
Created: 2018-09-12
Species: All species
Last Modified: 2018-09-12
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.