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A polymorphism in lipoprotein lipase affects the severity of Alzheimer's disease pathophysiology.

Authors: Blain, Jean-François  Aumont, Nicole  Théroux, Louise  Dea, Doris  Poirier, Judes 
Citation: Blain JF, etal., Eur J Neurosci. 2006 Sep;24(5):1245-51. doi: 10.1111/j.1460-9568.2006.05007.x. Epub 2006 Sep 8.
Pubmed: (View Article at PubMed) PMID:16965549
DOI: Full-text: DOI:10.1111/j.1460-9568.2006.05007.x

Emerging evidences indicate a role for lipoprotein lipase (LPL) in degenerative states. Genetic variations in the LPL gene were previously associated to lipid imbalance and coronary artery disease (CAD) risk and severity, a condition that shares pathological features with common Alzheimer's disease (AD). To evaluate whether these genetic variations associate with the risk and pathophysiology of common AD, autopsy-confirmed patients (242 controls, 153 AD) were genotyped for a PvuII single nucleotide polymorphism (SNP; rs285; referred to as the P+ allele) of LPL. Brain LPL mRNA levels, cholesterol levels, amyloid concentration, senile plaques and neurofibrillary tangles density counts were measured and contrasted with specific LPL genotypes. When adjusted for age and sex, homozygosity for the P+ allele resulted in an odds ratio of 2.3 for the risk of developing AD. More importantly, we report that the presence of the P+ allele of LPL significantly affects its mRNA expression level (n = 51; P = 0.026), brain tissue cholesterol levels (n = 55; P = 0.0013), neurofibrillary tangles (n = 52; P = 0.025) and senile plaque (n = 52; P = 0.022) densities. These results indicate that a common polymorphism in the lipoprotein lipase gene modulates the risk level for sporadic AD in the eastern Canadian population but more importantly, indirectly modulates the pathophysiology of the brain in autopsy-confirmed cases.


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CRRD Object Information
CRRD ID: 13793393
Created: 2018-10-05
Species: All species
Last Modified: 2018-10-05
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.