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Circulating coupling factor 6 in human hypertension: role of reactive oxygen species.

Authors: Osanai, Tomohiro  Sasaki, Satoko  Kamada, Takaatsu  Fujiwara, Naoto  Nakano, Takao  Tomita, Hirofumi  Matsunaga, Toshiro  Magota, Koji  Okumura, Ken 
Citation: Osanai T, etal., J Hypertens. 2003 Dec;21(12):2323-8. doi: 10.1097/01.hjh.0000098161.70956.08.
Pubmed: (View Article at PubMed) PMID:14654753
DOI: Full-text: DOI:10.1097/01.hjh.0000098161.70956.08


OBJECTIVE: Coupling factor 6 is an endogenous inhibitor of prostacyclin synthesis and might function as an endogenous vasoconstrictor in the fashion of a circulating hormone in rats. We investigated the role of coupling factor 6 in human hypertension.
METHODS AND RESULTS: The patients with essential hypertension (EH) (n = 30) received a series of normal salt diet (12 g salt/day) for 3 days, low salt diet (2 g salt/day) for 7 days, and high salt diet (20-23 g salt/day) for 7 days. Normotensive control subjects (n = 27) received normal and low salt diets. The plasma level of coupling factor 6, measured by radioimmunoassay, during normal salt diet was higher in patients with EH than in normotensive subjects (17.6 +/- 1.7 versus 12.8 +/- 0.5 ng/ml, P < 0.01). Whereas the plasma level of coupling factor 6 was unchanged after salt restriction in normotensive subjects, it was decreased after salt restriction (from 12 g/day to 2 g/day) and was increased after salt loading (from 2 g/day to 20-23 g/day) in patients with EH. This increase in plasma level of coupling factor 6 was abolished by oral administration of ascorbic acid, but the level of blood pressure was unaffected. The percentage changes in plasma coupling factor 6 level after salt restriction and loading were positively correlated with those in mean blood pressure (r = 0.57, P < 0.01), and negatively correlated with those in plasma nitric oxide level (r = -0.51, P < 0.05).
CONCLUSION: These indicate that circulating coupling factor 6 is elevated in human hypertension and modulated by salt intake presumably via reactive oxygen species.

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CRRD Object Information
CRRD ID: 13800915
Created: 2018-10-22
Species: All species
Last Modified: 2018-10-22
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.