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No association between polymorphisms in the neprilysin promoter region and Swedish Alzheimer's disease patients.

Authors: Lilius, Lena  Forsell, Charlotte  Axelman, Karin  Winblad, Bengt  Graff, Caroline  Tjernberg, Lars 
Citation: Lilius L, etal., Neurosci Lett. 2003 Feb 6;337(2):111-3.
Pubmed: (View Article at PubMed) PMID:12527400

Amyloid beta-peptide (Abeta) deposition in brain is important in the development of Alzheimer's disease (AD). Neprilysin (NEP) appears to be the major Abeta degrading enzyme in vivo and reduced mRNA levels of NEP correlates with increased plaque density. We hypothesized that alterations in the NEP promoter region may alter NEP expression and thus be involved in the AD process. We investigated three putative important regions in the NEP promoter region; two dinucleotide-repeats (CA and GT) and a 480 base pair fragment. With fragment analysis and sequencing, 164 early-onset and 152 late-onset Swedish AD cases and 109 non-demented controls were investigated. No significant difference in the distribution of promoter polymorphisms between AD cases and controls were found in this study.


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CRRD Object Information
CRRD ID: 13801020
Created: 2018-10-26
Species: All species
Last Modified: 2018-10-26
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.