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UBTOR/KIAA1024 regulates neurite outgrowth and neoplasia through mTOR signaling.

Authors: Zhang, Hefei  Zhang, Quan  Gao, Ge  Wang, Xinjian  Wang, Tiantian  Kong, Zhitao  Wang, Guoxiang  Zhang, Cuizhen  Wang, Yun  Peng, Gang 
Citation: Zhang H, etal., PLoS Genet. 2018 Aug 6;14(8):e1007583. doi: 10.1371/journal.pgen.1007583. eCollection 2018 Aug.
Pubmed: (View Article at PubMed) PMID:30080879
DOI: Full-text: DOI:10.1371/journal.pgen.1007583

The mTOR signaling pathways regulate cell growth and are involved in multiple human diseases. Here, we identify UBTOR, a previously unannotated gene as a functional player in regulating cell growth and mTOR signaling. Reduction of UBTOR function in cultured hippocampal neurons and PC12 cells promotes neurite outgrowth. UBTOR depletion activates mTOR signaling and promotes cell growth, whilst UBTOR overexpression suppresses colony formation in cancer cell lines. Studies in cultured cells and zebrafish model show that UBTOR inhibits mTOR signaling by stabilizing the mTOR complex component DEPTOR, and ubtor gene disruption result in higher mTOR activity and aggravate HRAS(G12V) induced neoplasia in the zebrafish. Lastly, UBTOR depletion promotes tumor growth and mTOR signaling in a xenograft mouse model. Together, our results demonstrate how UBTOR regulates cell growth and neoplasia via mTOR signaling.


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CRRD Object Information
CRRD ID: 13825189
Created: 2018-11-21
Species: All species
Last Modified: 2018-11-21
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.