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Differential expression of BNIP family members of BH3-only proteins during the development and after axotomy in the rat.

Authors: Cho, Bongki  Choi, So Yoen  Park, Ok-Hee  Sun, Woong  Geum, Dongho 
Citation: Cho B, etal., Mol Cells. 2012 Jun;33(6):605-10. doi: 10.1007/s10059-012-0051-0. Epub 2012 May 23.
Pubmed: (View Article at PubMed) PMID:22639046
DOI: Full-text: DOI:10.1007/s10059-012-0051-0

The BNIPs (BCL2 and adenovirus E1B 19 kDa interacting proteins) are a subfamily of BCL2 family proteins typically containing a single BCL2 homology 3 (BH3) domain. BNIPs exert important roles in two major degradation processes in cells - apoptosis and autophagy. Although it is known that the function of BNIPs is transcriptionally regulated under hypoxic conditions in tumors, their regulation in the developing brain and neurons following the induction of apoptosis/autophagy is largely unknown. In this study, we demonstrate that three members of the BNIP family, BNIP1, BNIP3 and BNIP3L, are expressed in the developing brain with distinct brain region specificity. BNIP3 mRNA was especially enriched in the entorhinal cortex, raising a possibility that it may have additional biological functions in addition to its apoptotic and autophagic functions. Following starvation-induced autophagy induction, BNIP1 mRNA was selectively increased in cultured neurons. However, the apoptogenic chemical staurosporine failed to modulate the expression of BNIPs, which is in contrast to the marked induction of all BNIPs by glucose-oxygen deprivation. Finally, neonatal nerve axotomy, which triggers apoptosis in motoneurons, selectively enhanced BNIP3 mRNA expression. Collectively, these results suggest that the expression of BNIPs is differentially regulated depending on the stimuli, and BNIPs may exert unique biological functions.


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CRRD Object Information
CRRD ID: 14398458
Created: 2019-04-17
Species: All species
Last Modified: 2019-04-17
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.