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A 4-gene panel as a marker at chromosome 8q in Asian gastric cancer patients.

Authors: Cheng, Lei  Zhang, Qing  Yang, Sheng  Yang, Yanqing  Zhang, Wen  Gao, Hengjun  Deng, Xiaxing  Zhang, Qinghua 
Citation: Cheng L, etal., Genomics. 2013 Oct;102(4):323-30. doi: 10.1016/j.ygeno.2013.05.004. Epub 2013 May 28.
Pubmed: (View Article at PubMed) PMID:23722107
DOI: Full-text: DOI:10.1016/j.ygeno.2013.05.004

A widely held viewpoint is that the use of multiple markers, combined in some type of algorithm, will be necessary to provide high enough discrimination between diseased cases and non-diseased. We applied stepwise logistic regression analysis to identify the best combination of the 32 biomarkers at chromosome 8q on an independent public microarray test set of 80 paired gastric samples. A combination of SULF1, INTS8, ATP6V1C1, and GPR172A was identified with a prediction accuracy of 98.0% for discriminating carcinomas from adjacent noncancerous tissues in our previous 25 paired samples. Interestingly, the overexpression of SULF1 was associated with tumor invasion and metastasis. Function prediction analysis revealed that the 4-marker panel was mainly associated with acidification of intracellular compartments. Taken together, we found a 4-gene panel that accurately discriminated gastric carcinomas from adjacent noncancerous tissues and these results had potential clinical significance in the early diagnosis and targeted treatment of gastric cancer.

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CRRD Object Information
CRRD ID: 14700649
Created: 2019-08-08
Species: All species
Last Modified: 2019-08-08
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.