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Expression and the role of cathepsin H in human glioma progression and invasion.

Authors: Sivaparvathi, M  Sawaya, R  Gokaslan, ZL  Chintala, SK  Rao, JS 
Citation: Sivaparvathi M, etal., Cancer Lett 1996 Jun 24;104(1):121-6.
Pubmed: (View Article at PubMed) PMID:8640738

Proteinases and their inhibitors may play a role in the development and progression of many cancers. Several studies suggested that lysosomal proteinases cathepsin B, L, and D may be involved in the malignant progression of some human neoplastic diseases. In this study, we determined the levels of cathepsin H in human glioma progression and the significance of cathepsin H in glioma cell invasion. Levels of cathepsin H antigen were found to be significantly higher in glioblastomas and anaplastic astrocytoma when compared with normal brain tissue and low-grade gliomas. Western blotting confirmed the presence of authentic cathepsin H with a doublet at 27 and 25 kDa in normal brain tissue and tumor samples. However, the intensity of the band increased significantly in glioblastoma samples. Cathepsin H antibody inhibited the invasion of glioblastoma cell lines through Matrigel invasion assay. These data suggest that the tumor-specific increase in antigen may be a useful independent marker of tumor progression in central nervous system neoplasms.


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CRRD Object Information
CRRD ID: 1549417
Created: 2005-08-24
Species: All species
Last Modified: 2005-08-24
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.