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Genome screen for bone mineral density phenotypes in Fisher 344 and Lewis rat strains.

Authors: Koller, DL  Alam, I  Sun, Q  Liu, L  Fishburn, T  Carr, LG  Econs, MJ  Foroud, T  Turner, CH 
Citation: Koller DL, etal., Mamm Genome 2005 Aug;16(8):578-86. Epub 2005 Sep 14.
Pubmed: (View Article at PubMed) PMID:16180139
DOI: Full-text: DOI:10.1007/s00335-004-2459-0

In humans, peak bone mineral density (BMD) is the primary determinant of osteoporotic fracture risk among older individuals, with high peak BMD levels providing protection against osteoporosis in the almost certain event of bone loss later in life. A genome screen to identify quantitative trait loci (QTLs) contributing to areal BMD (aBMD) and volumetric BMD (vBMD) measurements at the lumbar spine and femoral neck was completed in 595 female F2 rats produced from reciprocal crosses of inbred Fischer 344 and Lewis rats. Significant evidence of linkage was detected to rat Chromosomes 1, 2, 8, and 10, with LOD scores above 8.0. The region on rat Chromosome 8 is syntenic to human Chromosome 15, where linkage to spine and femur BMD has been previously reported and confirmed in a sample of premenopausal women.


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CRRD Object Information
CRRD ID: 1553896
Created: 2005-10-04
Species: All species
Last Modified: 2005-10-04
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.