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Developmental expression of 5-HT 5A receptor mRNA in the rat brain.

Authors: Garcia-Alcocer, G  Sarabia-Altamirano, G  Martinez-Torres, A  Miledi, R 
Citation: Garcia-Alcocer G, etal., Neurosci Lett. 2005 May 6;379(2):101-5.
Pubmed: (View Article at PubMed) PMID:15823424
DOI: Full-text: DOI:10.1016/j.neulet.2004.12.049

In the central nervous system, serotonin (5-HT) may function as a mitogen as well as a neurotransmitter; and its early appearance suggests a potential role in development. The present experiments were done to determine the localization of the mRNA coding for the 5-HT 5A receptor during development of the rat brain. 5-HT 5A gene transcription was assessed by in situ hybridization, from E18 and during postnatal (PN) development. An intense signal of 5-HT 5A mRNA was found in the cerebral cortex and olfactory nucleus at E18, PN0 and PN5. A sharp decrease at PN11 was followed by an increase until reaching the adult level in the cerebral cortex; whereas in the olfactory nucleus, transcription remained weak. In contrast, in the hippocampal formation the signal was weak in the CA1, CA2 and CA3 regions at E18 and PO; increased at P5 and then decreased at P11 before attaining the adult level. We conclude that the gene coding for the 5-HT 5A receptor is already active in the embryonic rat brain and is differentially expressed during development.

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CRRD Object Information
CRRD ID: 1578542
Created: 2006-04-03
Species: All species
Last Modified: 2006-04-03
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.