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PERIOD1-associated proteins modulate the negative limb of the mammalian circadian oscillator.

Authors: Brown, SA  Ripperger, J  Kadener, S  Fleury-Olela, F  Vilbois, F  Rosbash, M  Schibler, U 
Citation: Brown SA, etal., Science. 2005 Apr 29;308(5722):693-6.
Pubmed: (View Article at PubMed) PMID:15860628
DOI: Full-text: DOI:10.1126/science.1107373

The clock proteins PERIOD1 (PER1) and PERIOD2 (PER2) play essential roles in a negative transcriptional feedback loop that generates circadian rhythms in mammalian cells. We identified two PER1-associated factors, NONO and WDR5, that modulate PER activity. The reduction of NONO expression by RNA interference (RNAi) attenuated circadian rhythms in mammalian cells, and fruit flies carrying a hypomorphic allele were nearly arrhythmic. WDR5, a subunit of histone methyltransferase complexes, augmented PER-mediated transcriptional repression, and its reduction by RNAi diminished circadian histone methylations at the promoter of a clock gene.


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CRRD Object Information
CRRD ID: 1579815
Created: 2006-05-16
Species: All species
Last Modified: 2006-05-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.