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Association between the tumor necrosis factor-alpha -308 G/A gene polymorphism and migraine.

Authors: Rainero, I  Grimaldi, LM  Salani, G  Valfre, W  Rivoiro, C  Savi, L  Pinessi, L 
Citation: Rainero I, etal., Neurology. 2004 Jan 13;62(1):141-3.
Pubmed: (View Article at PubMed) PMID:14718719

In a group of 299 migraine patients and 306 control subjects, the association of the -308 G/A polymorphism in the tumor necrosis factor-alpha gene (TNFalpha) with the occurrence and clinical characteristics of migraine was tested. Homozygosity for the G allele was associated with an increased risk of migraine (odds ratio [OR] = 2.85, p < 0.001). When the patients were divided into subgroups, the association was confirmed in patients affected by migraine without aura (OR = 3.30, p < 0.001) but not in migraine with aura. These data suggest that the TNFalpha gene or a linked locus significantly modulates the risk for migraine.


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CRRD Object Information
CRRD ID: 1580316
Created: 2006-07-21
Species: All species
Last Modified: 2006-07-21
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.