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Modulation of IR/PTP1B interaction and downstream signaling in insulin sensitive tissues of MSG-rats.

Authors: Hirata, AE  Alvarez-Rojas, F  Carvalheira, JB  Carvalho, CR  Dolnikoff, MS  Abdalla Saad, MJ 
Citation: Hirata AE, etal., Life Sci. 2003 Aug 1;73(11):1369-81.
Pubmed: (View Article at PubMed) PMID:12850498

PTP1B has been shown to be a negative regulator of the insulin signal transduction in insulin resistant states. Herein we investigated IR/PTP1B interaction and downstream signaling in insulin sensitive tissues of 10 and 28-week-old MSG-insulin resistant rats which represent different stages of insulin resistance. Our results demonstrated that the increase in PTP1B expression and/or association with IR in MSG animals may contribute to the impaired insulin signaling mainly in liver and muscle. Although, adipose tissue of 10-week-old MSG rats showed higher PTP1B expression and IR/PTP1B interaction, they were not sufficient to impair all insulin signaling since IRS-2 phosphorylation and association with PI3-kinase and Akt serine phosphorylation were increased, which may contribute for the increased adiposity of these animals. In 28-week-old-MSG rats there was an increase in IR/PTP1B interaction and reduced insulin signaling in liver, muscle and adipocytes, and a more pronounced insulin resistance.


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CRRD Object Information
CRRD ID: 1580595
Created: 2006-08-15
Species: All species
Last Modified: 2006-08-15
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.