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High expression of YB-1 gene in erythroid cells in patients with refractory anemia.

Authors: Yokoyama, H  Harigae, H  Takahashi, S  Kameoka, J  Miyamura, K  Ishizawa, K  Kaku, M  Sasaki, T 
Citation: Yokoyama H, etal., Int J Hematol. 2003 Oct;78(3):213-8.
Pubmed: (View Article at PubMed) PMID:14604279

It has been shown that aberrant expression of a transcription factor, GATA-1, leads to maturation arrest and transformation of erythroid cells. We previously reported that a multifunctional protein, YB-1, was expressed strongly in the spleen of a GATA-1 mutant mouse, which was filled with transformed erythroblasts. This finding suggested that YB-1 has roles in erythropoiesis. In this study, we examined in vivo expression of YB-1 messenger RNA (mRNA) in bone marrow erythroid cells and erythroid leukemic cell lines. During erythroid differentiation of erythroid leukemic cell lines, the expression level of YB-1 mRNA was highest at the early phase of differentiation and then decreased. In human bone marrow cells, the in vivo expression level of YB-1 mRNA was higher in glycophorin A-positive cells than in glycophorin A-negative cells. An interesting finding was that expression of YB-1 was higher in erythroblasts in myelodysplastic syndrome-refractory anemia (MDS-RA) than in normal cells. The findings suggested that YB-1 functions in the early stage of erythropoiesis and that aberrant expression of this protein may induce hematological diseases such as MDS.


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CRRD Object Information
CRRD ID: 1580637
Created: 2006-08-17
Species: All species
Last Modified: 2006-08-17
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.