Von Willebrand factor antigen levels in Behcet disease.

Authors: Beyan, E  Sadikoglu, B  Ertugrul, E  Beyan, C 
Citation: Beyan E, etal., Am J Hematol. 2005 May;79(1):70-2.
Pubmed: (View Article at PubMed) PMID:15849757
DOI: Full-text: DOI:10.1002/ajh.20317

High von Willebrand factor antigen (vWF:Ag) levels can be found due to vascular endothelial injury in Behcet disease. The aim of this study is to evaluate whether there is any relationship between vWF:Ag levels and vascular or other organ involvements and acute-phase reactants in Behcet disease. Fifteen controls and 17 Behcet's patients were included; 10 had oral ulcers, 5 had genital ulcers, 3 had skin lesions, 6 had ocular involvement, 5 had arthritis, and 6 had vascular involvement. VWF:Ag levels were higher in Behcet's patients than controls. VWF:Ag levels in Behcet's patients with oral ulcers, genital ulcers, and ocular and vascular involvement were statistically higher than in the control group. Differences between vWF:Ag levels in Behcet's patients with and without organ involvement were not statistically significant. A linear correlation between serum ferritin levels and vWF:Ag levels was observed. These results demonstrate that elevated levels of plasma vWF:Ag are related to Behcet disease exacerbation rather than vascular involvement.

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CRRD Object Information
CRRD ID: 1580642
Created: 2006-08-18
Species: All species
Last Modified: 2006-08-18
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.