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Protein Z influences the prothrombotic phenotype in Factor V Leiden patients.

Authors: Kemkes-Matthes, B  Nees, M  Kuhnel, G  Matzdorff, A  Matthes, KJ 
Citation: Kemkes-Matthes B, etal., Thromb Res. 2002 May 15;106(4-5):183-5.
Pubmed: (View Article at PubMed) PMID:12297123

Protein Z enhances the inhibition of factor Xa by protein Z-dependent protease inhibitor (ZPI). Thus, diminution of protein Z should induce prothrombotic tendency due to lowered cofactor activity for ZPI. In Factor V Leiden mice, prothrombotic tendency of severe diminution or lack of protein Z was demonstrated. We here present first studies in humans, indicating that diminution of protein Z in factor V Leiden patients aggravates thromboembolic risk.


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CRRD Object Information
CRRD ID: 1580720
Created: 2006-08-21
Species: All species
Last Modified: 2006-08-21
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.