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Cardiac hypertrophy in vivo is associated with increased expression of the ribosomal gene transcription factor UBF.

Authors: Brandenburger, Y  Arthur, JF  Woodcock, EA  Du, XJ  Gao, XM  Autelitano, DJ  Rothblum, LI  Hannan, RD 
Citation: Brandenburger Y, etal., FEBS Lett. 2003 Jul 31;548(1-3):79-84.
Pubmed: (View Article at PubMed) PMID:12885411

The ribosomal DNA transcription-specific factor, UBF, is a key target for the regulation of ribosomal RNA synthesis and hypertrophic growth of isolated neonatal cardiomyocytes. In this study, we have examined whether UBF expression is also an important determinant of cardiac growth rates in vivo. We show that rDNA transcription, rRNA synthesis and UBF expression in left ventricular myocytes isolated from mice 1-6 weeks following transverse aortic constriction were significantly increased (2.5-3.5-fold) compared to the levels in myocytes from the left ventricle of sham-operated mice.


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CRRD Object Information
CRRD ID: 1580791
Created: 2006-08-25
Species: All species
Last Modified: 2006-08-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.