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Yin Yang 1 represses alpha-myosin heavy chain gene expression in pathologic cardiac hypertrophy.

Authors: Mariner, PD  Luckey, SW  Long, CS  Sucharov, CC  Leinwand, LA 
Citation: Mariner PD, etal., Biochem Biophys Res Commun. 2005 Jan 7;326(1):79-86.
Pubmed: (View Article at PubMed) PMID:15567155
DOI: Full-text: DOI:10.1016/j.bbrc.2004.11.008

In the work presented here, we elucidate a mechanism for the repression of alpha-myosin heavy chain (MyHC) during pathological cardiac hypertrophy. We demonstrate that the transcription factor Yin Yang 1 (YY1) significantly decreases endogenous alpha-MyHC mRNA and protein expression in neonatal rat ventricular myocytes. Furthermore, mutation of the YY1 binding sites in the proximal rat alpha-MyHC promoter increases promoter activity and alleviates YY1-mediated repression of the promoter. Despite the presence of 5 sites that bind YY1, only one site, located at -94bp of the rat alpha-MyHC promoter, is both necessary and sufficient for pathological repression of the promoter by phorbol esters, revealing a unique mechanism for the repression of alpha-MyHC expression during cardiac hypertrophy.


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CRRD Object Information
CRRD ID: 1580832
Created: 2006-08-28
Species: All species
Last Modified: 2006-08-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.