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Model of functional cardiac aging: young adult mice with mild overexpression of serum response factor.

Authors: Zhang, X  Azhar, G  Furr, MC  Zhong, Y  Wei, JY 
Citation: Zhang X, etal., Am J Physiol Regul Integr Comp Physiol. 2003 Sep;285(3):R552-60.
Pubmed: (View Article at PubMed) PMID:12909581
DOI: Full-text: DOI:10.1152/ajpregu.00631.2002

Serum response factor (SRF) is an important transcription factor that may have a role in the maintenance of cardiac structure and function. The level of SRF mRNA expression increases approximately 16% in the hearts of mice during adult aging. To model the effect of mild SRF elevation in the aging heart, transgenic mice with low levels of SRF overexpression were generated. By 6 mo of age, the transgenic mice had a 19% increase of heart-to-body weight ratio compared with nontransgenic mice. In addition, they had a 12% increase in myocyte size, a 6.7% increase in collagen deposition, and altered gene expression of a number of muscle-specific and cardiac genes. Doppler echocardiography revealed that these transgenic mice had increased left ventricular wall thickness and decreased left ventricular (LV) volumes, increased LV stiffness with 20% reduction in early diastolic LV filling (peak E), and 35% decline in peak E-to-peak A (late diastolic filling) ratio. The observed changes, especially those in the E/A ratio, are similar to those seen clinically in late life as a part of human adult myocardial aging.


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CRRD Object Information
CRRD ID: 1581425
Created: 2006-10-04
Species: All species
Last Modified: 2006-10-04
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.